Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | FABP3 | P05413 | 4/20 | 0.46 |
| ▸ | CETP | P11597 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL8598208 | 0.87 | EPHX2 (0.47) | CES2CES1EPHX2HDAC3HDAC4 | |
| Stearic Acid SCHEMBL4599006 | 0.87 | CES2 (0.49) | CES2CES1EPHX2HDAC3HDAC4 | |
| Dodecanoate SCHEMBL30363216 | 0.83 | HDAC3 (0.54) | CES2CES1EPHX2HDAC3HDAC4 | |
| Decanoic Acid SCHEMBL31119049 | 0.80 | SLC7A5 (0.59) | CES2CES1EPHX2HDAC3HDAC4 | |
| Decanoic Acid SCHEMBL29031142 | 0.80 | SLC7A5 (0.59) | CES2CES1EPHX2HDAC3HDAC4 | |
| Stearic Acid SCHEMBL11045268 | 0.80 | HDAC3 (0.51) | CES2CES1EPHX2HDAC3HDAC4 | |
| Octanoic Acid SCHEMBL18812646 | 0.80 | ASAH1 (0.52) | CES2CES1PPARGFABP3PPARA | |
| Dodecanoate SCHEMBL673994 | 0.80 | HDAC3 (0.51) | CES2CES1EPHX2HDAC3HDAC4 | |
| Stearic Acid SCHEMBL4454939 | 0.80 | HDAC3 (0.51) | CES2CES1EPHX2HDAC3HDAC4 | |
| Dodecanoate SCHEMBL4454933 | 0.80 | HDAC3 (0.51) | CES2CES1EPHX2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309794-B1 | No-post-cure method of curing polyacrylate polymers | ZEON CHEMICALS INC (US) | 1998-01-28 | — | — | EP | claimed |
| EP-0362459-B1 | Polyacrylate polymers utilizing substituted urea retarder | ZEON CHEMICALS USA INC (US) | 1994-08-10 | — | — | EP | claimed |
| US-5081194-A | Quaternary ammonium or phosphonium curing agent | ZEON CHEMICALS U.S.A., INC. (US) | 1992-01-14 | — | — | US | claimed |
| US-5079304-A | Curable | ZEON CHEMICALS U.S.A., INC. (US) | 1992-01-07 | — | — | US | claimed |
| EP-0362459-A1 | Polyacrylate polymers utilizing substituted urea retarder | Zeon Chemicals USA, Inc. (US) | 1990-04-11 | — | — | EP | claimed |
| EP-0309794-A2 | No-post-cure method of curing polyacrylate polymers | Zeon Chemicals USA, Inc. (US) | 1989-04-05 | — | — | EP | claimed |
| EP-0309794-B1 | No-post-cure method of curing polyacrylate polymers | ZEON CHEMICALS INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0362459-B1 | Polyacrylate polymers utilizing substituted urea retarder | ZEON CHEMICALS USA INC (US) | 1994-08-10 | — | — | EP | disclosed |
| US-5081194-A | Quaternary ammonium or phosphonium curing agent | ZEON CHEMICALS U.S.A., INC. (US) | 1992-01-14 | — | — | US | disclosed |
| US-5079304-A | Curable | ZEON CHEMICALS U.S.A., INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-5008345-A | Two-Part Curing System Containing A Metallic Acid Salt And An Ammonium Or Phosphonium Quaternary Salt | ZEON CHEMICAL USA, INC. (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0362459-A1 | Polyacrylate polymers utilizing substituted urea retarder | Zeon Chemicals USA, Inc. (US) | 1990-04-11 | — | — | EP | disclosed |
| EP-0309794-A2 | No-post-cure method of curing polyacrylate polymers | Zeon Chemicals USA, Inc. (US) | 1989-04-05 | — | — | EP | disclosed |