Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 6/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142420 | 0.88 | ALDH1A1 (0.47) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8594440 | 0.83 | TSHR (0.39) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8874715 | 0.73 | TSHR (0.52) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| Tecnazene SCHEMBL64355 | 0.72 | TSHR (1.00) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| Tecnazene SCHEMBL3014845 | 0.72 | TSHR (1.00) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8599654 | 0.72 | ALDH1A1 (0.35) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL8872587 | 0.69 | TSHR (0.46) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8873670 | 0.69 | TSHR (0.46) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8873871 | 0.69 | TSHR (0.46) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8872392 | 0.68 | TSHR (0.45) | TSHRGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |