Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596333 | 0.85 | DRD4 (0.55) | POLBCHRM4L3MBTL1 | |
| SCHEMBL8595024 | 0.85 | DRD4 (0.55) | POLBCHRM4L3MBTL1 | |
| SCHEMBL8595026 | 0.85 | DRD4 (0.55) | POLBCHRM4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8598902 | 0.84 | DRD4 (0.54) | POLBCHRM4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8595172 | 0.84 | DRD4 (0.54) | POLBCHRM4L3MBTL1 | |
| SCHEMBL10734821 | 0.83 | GRIN2B (0.64) | POLBMEN1KMT2ASMN1; SMN2CHRM4 | |
| SCHEMBL10735790 | 0.79 | GRIN2B (0.59) | CHRM4 | |
| SCHEMBL4246345 | 0.78 | PARP10 (0.64) | POLBMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL6803381 | 0.77 | MAOB (0.61) | SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4246343 | 0.77 | MEN1 (0.55) | POLBMEN1KMT2ASMN1; SMN2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0648744-B1 | Phenylalkanolamine derivatives as antagonists of the NMDA receptor | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0648744-A1 | Phenylalkanolamine derivatives as antagonists of the NMDA receptor | F. HOFFMANN-LA ROCHE AG (CH) | 1995-04-19 | — | — | EP | disclosed |