Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.46 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.46 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8598555 | 0.80 | CYP1A2 (0.60) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL12727872 | 0.78 | CYP1A2 (0.57) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL27543660 | 0.78 | CYP1A2 (0.57) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL1742521 | 0.78 | CYP1A2 (0.57) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL27961047 | 0.76 | CYP1A2 (0.68) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL8599963 | 0.76 | CYP1A2 (0.59) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL28738722 | 0.76 | CYP1A2 (0.55) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL8600350 | 0.76 | IDO1 (0.56) | CYP1A2ALDH1A1TSHRMAPTAKR1C3 | |
| SCHEMBL3124261 | 0.75 | CYP1A2 (0.67) | CYP1A2ALOX5ALDH1A1GPR35TP53 | |
| SCHEMBL3776333 | 0.75 | IDO1 (0.63) | CYP1A2ALOX5ALDH1A1GPR35TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723973-B1 | Nucleoside phosphorothioate derivatives, synthesis and use thereof | KING S COLLEGE LONDON (GB) | 1998-10-21 | — | — | EP | disclosed |
| US-5708161-A | Nucleoside phosphorothioate derivatives, synthesis and use thereof | KING'S COLLEGE LONDON (GB) | 1998-01-13 | — | — | US | disclosed |
| EP-0723973-A1 | Nucleoside phosphorothioate derivatives, synthesis and use thereof | KING'S COLLEGE LONDON (GB) | 1996-07-31 | — | — | EP | disclosed |