SCHEMBL859912

SCHEMBL859912

O=C(ON1C(=O)c2ccc(Oc3ccc4c(c3)C(=O)N(OC(=O)c3c(F)c(F)c(F)c(F)c3F)C4=O)cc2C1=O)c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.51
POLB P06746 4/20 0.47
LPAR3 Q9UBY5 2/20 0.46
LPAR1 Q92633 1/20 0.46
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 3/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
HTT P42858 1/20 0.43
HSD17B10 Q99714 3/20 0.43
MAPK1 P28482 2/20 0.43
BRD4 O60885 1/20 0.41
HPGD P15428 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
PKM P14618 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL859699 0.83 ALDH1A1 (0.43) TDP1POLBALDH1A1KDM4EKMT2A
SCHEMBL7451607 0.82 ALDH1A1 (0.41) POLBALDH1A1KDM4EKMT2AMEN1
SCHEMBL860126 0.81 ALDH1A1 (0.45) POLBALDH1A1KDM4EKMT2AMEN1
SCHEMBL859763 0.79 KDM4E (0.37) TDP1POLBALDH1A1KDM4EHSD17B10
SCHEMBL860087 0.78 TDP1 (0.52) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL859692 0.77 POLB (0.60) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL859769 0.76 POLB (0.46) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL860271 0.72 MAPT (0.46) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL3825755 0.71 KDM4E (0.46) TDP1POLBLPAR3LPAR1ALDH1A1
SCHEMBL859768 0.71 TDP1 (0.51) TDP1POLBLPAR3LPAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
EP-2100731-A2 Lithographic printing plate precursor and method of lithographic printing Fujifilm Corporation (JP) 2009-09-16 EP disclosed