SCHEMBL860087

SCHEMBL860087

O=C(ON1C(=O)c2ccc(Oc3ccc4c(c3)C(=O)N(OC(=O)c3ccccc3)C4=O)cc2C1=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.52
KMT2A Q03164 4/20 0.49
POLB P06746 3/20 0.49
MEN1 O00255 2/20 0.49
MAPK1 P28482 2/20 0.49
LPAR3 Q9UBY5 2/20 0.47
LPAR1 Q92633 1/20 0.47
BRD4 O60885 1/20 0.45
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 2/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
AKR1C3 P42330 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL491136 0.84 ALDH1A1 (0.57) KMT2APOLBALDH1A1KDM4ECYP1A2
SCHEMBL859698 0.84 APEX1 (0.52) TDP1KMT2APOLBMEN1ALDH1A1
SCHEMBL29082812 0.82 ALDH1A1 (0.56) KMT2APOLBALDH1A1KDM4ECYP1A2
SCHEMBL859769 0.80 POLB (0.46) TDP1KMT2APOLBMEN1MAPK1
SCHEMBL16142447 0.79 ALDH1A1 (0.50) KMT2APOLBMAPK1ALDH1A1KDM4E
SCHEMBL860271 0.79 MAPT (0.46) TDP1KMT2APOLBMEN1LPAR3
SCHEMBL859692 0.78 POLB (0.60) TDP1KMT2APOLBMEN1MAPK1
SCHEMBL859912 0.78 TDP1 (0.51) TDP1KMT2APOLBMEN1MAPK1
SCHEMBL22957153 0.78 ALDH1A1 (0.50) KMT2APOLBMAPK1ALDH1A1HSD17B10
SCHEMBL11756900 0.77 ALDH1A1 (0.49) KMT2APOLBMAPK1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
EP-2100731-A2 Lithographic printing plate precursor and method of lithographic printing Fujifilm Corporation (JP) 2009-09-16 EP disclosed