Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8598184 | 0.87 | PPARA (0.46) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8562791 | 0.79 | PIK3C2B (0.41) | KDM4EALDH1A1MAPTLMNAAPEX1 | |
| SCHEMBL8600004 | 0.77 | PIK3C2B (0.45) | KDM4EPIK3C2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8598178 | 0.77 | CYP2C9 (0.47) | KDM4EALDH1A1MAPTTP53LMNA | |
| SCHEMBL8601846 | 0.76 | PPARG (0.48) | KDM4EALDH1A1MAPTTP53PIK3C2B | |
| SCHEMBL8597750 | 0.74 | DCTPP1 (0.48) | KDM4EPIK3C2BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8646317 | 0.73 | TSHR (0.41) | KDM4EMAPK1ALDH1A1MAPTLMNA | |
| SCHEMBL8602363 | 0.70 | PIK3C2B (0.52) | KDM4EALDH1A1MAPTTP53LMNA | |
| SCHEMBL1587303 | 0.67 | MAPT (0.60) | ALDH1A1MAPTLMNASMN1; SMN2TSHR | |
| SCHEMBL8602280 | 0.66 | KDM4E (0.41) | KDM4EALDH1A1MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |