Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2B | O00750 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600239 | 0.86 | TSHR (0.41) | KDM4EHPGDCYP2C9CYP1A2CYP2C19 | |
| SCHEMBL8598178 | 0.84 | CYP2C9 (0.47) | PIK3C2BKDM4EHPGDPPARGCYP2C9 | |
| SCHEMBL8601846 | 0.82 | PPARG (0.48) | PIK3C2BKDM4EHPGDPPARGALDH1A1 | |
| SCHEMBL8599284 | 0.79 | KDM4E (0.44) | PIK3C2BKDM4ECYP2C9CYP1A2CYP2C19 | |
| SCHEMBL8597750 | 0.78 | DCTPP1 (0.48) | PIK3C2BKDM4EHPGDPPARGCYP2C9 | |
| SCHEMBL8600004 | 0.76 | PIK3C2B (0.45) | PIK3C2BKDM4EHPGDPPARGCYP2C9 | |
| SCHEMBL8597372 | 0.74 | PTGES (0.45) | BRD4CREBBP | |
| SCHEMBL8602363 | 0.74 | PIK3C2B (0.52) | PIK3C2BKDM4ECYP2C9CYP1A2CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL8603670 | 0.71 | ALDH1A1 (0.43) | KDM4EHPGDCYP2C9CYP1A2CYP2C19 | |
| SCHEMBL8600049 | 0.69 | KDM4E (0.51) | KDM4EHPGDPPARGALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |