Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859938 | 1.00 | HRH4 (0.46) | HRH4RAB9AMAPTNPC1HRH1 | |
| SCHEMBL861160 | 0.88 | HRH4 (0.48) | HRH4RAB9AMAPTNPC1CCND3 | |
| SCHEMBL861161 | 0.88 | HRH4 (0.48) | HRH4RAB9AMAPTNPC1CCND3 | |
| SCHEMBL1588917 | 0.88 | HRH4 (0.46) | HRH4RAB9AMAPTNPC1HRH1 | |
| SCHEMBL1589899 | 0.87 | HRH4 (0.64) | HRH4 | |
| SCHEMBL847193 | 0.81 | ADRB1 (0.50) | HRH4RAB9AMAPTNPC1CHRNB2 | |
| SCHEMBL860364 | 0.76 | HRH4 (0.70) | HRH4 | |
| SCHEMBL860365 | 0.76 | HRH4 (0.70) | HRH4 | |
| SCHEMBL860990 | 0.76 | HRH4 (0.44) | HRH4RAB9ANPC1TP53 | |
| SCHEMBL860989 | 0.76 | HRH4 (0.44) | HRH4RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524363-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | claimed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | claimed |