Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861161 | 1.00 | HRH4 (0.48) | HRH4KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL859937 | 0.88 | HRH4 (0.46) | HRH4NPC1RAB9AMAPTCCND3 | |
| SCHEMBL859938 | 0.88 | HRH4 (0.46) | HRH4NPC1RAB9AMAPTCCND3 | |
| SCHEMBL1588725 | 0.87 | HRH4 (0.48) | HRH4KDM4EALDH1A1HPGD | |
| SCHEMBL13574769 | 0.86 | HRH4 (0.67) | HRH4 | |
| SCHEMBL847541 | 0.86 | HRH4 (0.67) | HRH4 | |
| SCHEMBL847981 | 0.79 | ADRB1 (0.47) | HRH4KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL860364 | 0.79 | HRH4 (0.70) | HRH4 | |
| SCHEMBL860365 | 0.79 | HRH4 (0.70) | HRH4 | |
| SCHEMBL860989 | 0.78 | HRH4 (0.44) | HRH4KDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524363-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | claimed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | claimed |