Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8598838 | 0.88 | TP53 (0.43) | TP53HTTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8596981 | 0.86 | TP53 (0.44) | TP53HTTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL8599275 | 0.85 | TP53 (0.42) | TP53HTTALDH1A1MMP2L3MBTL1 | |
| SCHEMBL8603067 | 0.85 | L3MBTL1 (0.45) | TP53HTTALDH1A1KDM4EMMP2 | |
| SCHEMBL8600307 | 0.85 | TP53 (0.44) | TP53HTTALDH1A1MMP2L3MBTL1 | |
| SCHEMBL8601161 | 0.85 | TP53 (0.46) | TP53HTTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL8597757 | 0.85 | L3MBTL1 (0.46) | TP53HTTALDH1A1MMP2L3MBTL1 | |
| SCHEMBL8596007 | 0.84 | TP53 (0.51) | TP53HTTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL8596165 | 0.83 | TP53 (0.45) | TP53HTTCYP1A2CYP2C9MMP2 | |
| SCHEMBL8598943 | 0.83 | TP53 (0.40) | TP53ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |