Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488793 | 0.73 | NQO1 (0.74) | SMN1; SMN2LMNANQO1ALDH1A1HPGD | |
| SCHEMBL14175640 | 0.69 | NQO1 (0.58) | SMN1; SMN2LMNANQO1ALDH1A1HPGD | |
| SCHEMBL16823798 | 0.69 | HTT (0.43) | SMN1; SMN2NQO1ALDH1A1MAPTTSHR | |
| SCHEMBL23542447 | 0.68 | KCNH2 (0.36) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL15201648 | 0.68 | NQO1 (0.64) | SMN1; SMN2LMNANQO1ALDH1A1HPGD | |
| Ammonia Solution, Strong SCHEMBL27718462 | 0.68 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1MAPTGAATSHR | |
| SCHEMBL5188545 | 0.67 | NQO1 (0.70) | SMN1; SMN2LMNANQO1ALDH1A1KDM4E | |
| SCHEMBL22912519 | 0.67 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL16373730 | 0.67 | RAB9A (0.36) | SMN1; SMN2ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL10154714 | 0.67 | KCNH2 (0.38) | SMN1; SMN2ALDH1A1MAPTTSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813410-A4 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-08-19 | — | — | EP | disclosed |
| EP-0813410-A1 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-12-29 | — | — | EP | disclosed |