SCHEMBL8600285

SCHEMBL8600285

CCc1cn(-c2cccc(C(F)(F)F)c2)/c(=N\C(=O)NC)o1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SCN2B O60939 2/20 0.39
SCN1B Q07699 2/20 0.39
SCN5A Q14524 2/20 0.39
SCN9A Q15858 2/20 0.39
SCN1A P35498 1/20 0.38
BRD9 Q9H8M2 1/20 0.37
HTT P42858 2/20 0.37
NOTUM Q6P988 1/20 0.37
LMNA P02545 1/20 0.36
POLB P06746 3/20 0.36
ALDH1A1 P00352 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
KDM4E B2RXH2 1/20 0.35
KDM4C Q9H3R0 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8600287 1.00 SCN2B (0.39) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL8568280 0.92 LMNA (0.42) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL8568283 0.92 LMNA (0.42) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL8566820 0.89 NOTUM (0.40) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL8566821 0.89 NOTUM (0.40) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL8570049 0.75 HTT (0.41) BRD9HTTNOTUMLMNAALDH1A1
SCHEMBL8570769 0.74 NOTUM (0.45) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL8570767 0.74 NOTUM (0.45) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL4853368 0.73 SCN2B (0.44) SCN2BSCN1BSCN5ASCN9ASCN1A
SCHEMBL4853360 0.73 SCN2B (0.44) SCN2BSCN1BSCN5ASCN9ASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998000408-A1 N-PHENYLIMINO HETEROCYCLIC DERIVATIVES AND THEIR USE AS HERBICIDES NOVARTIS AG (CH) 1998-01-08 WO disclosed