Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | LDLR | P01130 | 3/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846515 | 0.88 | TRPV1 (0.48) | TRPV1EPHX1BACE1LDLRMEN1 | |
| SCHEMBL847005 | 0.81 | TRPV1 (0.72) | TRPV1NPC1 | |
| SCHEMBL846060 | 0.81 | TRPV1 (0.72) | TRPV1NPC1 | |
| SCHEMBL847493 | 0.80 | TRPV1 (0.70) | TRPV1NPC1 | |
| SCHEMBL860046 | 0.78 | TRPV1 (0.67) | TRPV1BACE1RXFP1MEN1KMT2A | |
| SCHEMBL847374 | 0.78 | NAMPT (0.45) | TRPV1CTNNB1TCF7L2NAMPTNPC1 | |
| SCHEMBL846205 | 0.75 | TRPV1 (0.45) | TRPV1MEN1KMT2ACNR1S1PR1 | |
| SCHEMBL846298 | 0.74 | TRPV1 (0.51) | TRPV1EPHX1RXFP1NAMPTNPC1 | |
| SCHEMBL846670 | 0.73 | TRPV1 (0.55) | TRPV1CTNNB1TCF7L2NAMPTNPC1 | |
| SCHEMBL11192383 | 0.72 | SMN1; SMN2 (0.54) | EPHX1MEN1KMT2AHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |