Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846514 | 0.88 | TRPV1 (0.68) | TRPV1LMNAS1PR1KDM4EBACE1 | |
| SCHEMBL847137 | 0.80 | TRPV1 (1.00) | TRPV1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL846061 | 0.80 | TRPV1 (1.00) | TRPV1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL847641 | 0.79 | TRPV1 (0.98) | TRPV1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL860045 | 0.78 | TRPV1 (0.48) | TRPV1S1PR1BACE1MEN1NPC1 | |
| SCHEMBL847375 | 0.77 | TRPV1 (0.58) | TRPV1MAPTMEN1NPC1RAB9A | |
| SCHEMBL846204 | 0.76 | TRPV1 (0.64) | TRPV1S1PR1KDM4EMEN1KMT2A | |
| SCHEMBL846299 | 0.74 | TRPV1 (0.74) | TRPV1S1PR1KDM4EMAPTNPC1 | |
| SCHEMBL846980 | 0.73 | TRPV1 (0.80) | TRPV1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL846665 | 0.71 | TRPV1 (0.72) | TRPV1KDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |