Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846670 | 0.84 | TRPV1 (0.55) | NAMPTHTR2CMCHR1CTSLCTSS | |
| SCHEMBL847375 | 0.78 | TRPV1 (0.58) | HTR2CMCHR1TRPV1NPC1RAB9A | |
| SCHEMBL860045 | 0.78 | TRPV1 (0.48) | NAMPTTRPV1NPC1S1PR1CTNNB1 | |
| SCHEMBL846639 | 0.75 | RAB9A (0.59) | HTR2CMCHR1NPC1RAB9APOLB | |
| SCHEMBL847747 | 0.75 | TRPV1 (0.52) | HTR2CMCHR1TRPV1NPC1RAB9A | |
| SCHEMBL845830 | 0.75 | TRPV1 (0.52) | HTR2CMCHR1TRPV1NPC1RAB9A | |
| SCHEMBL847005 | 0.75 | TRPV1 (0.72) | TRPV1NPC1RAB9A | |
| SCHEMBL846060 | 0.75 | TRPV1 (0.72) | TRPV1NPC1RAB9A | |
| SCHEMBL847493 | 0.74 | TRPV1 (0.70) | TRPV1NPC1RAB9A | |
| SCHEMBL846515 | 0.73 | TRPV1 (0.48) | NAMPTTRPV1NPC1RAB9AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |