Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTR1F | P30939 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846980 | 0.84 | TRPV1 (0.80) | TRPV1KCNH2NPC1RAB9A | |
| SCHEMBL847374 | 0.78 | NAMPT (0.45) | TRPV1MCHR1NPC1RAB9APOLB | |
| SCHEMBL860046 | 0.77 | TRPV1 (0.67) | TRPV1KCNH2MAPTNPC1RAB9A | |
| SCHEMBL846639 | 0.76 | RAB9A (0.59) | MAPTMCHR1NPC1RAB9APOLB | |
| SCHEMBL845831 | 0.75 | TRPV1 (0.75) | TRPV1MCHR1NPC1RAB9APOLB | |
| SCHEMBL847137 | 0.74 | TRPV1 (1.00) | TRPV1NPC1RAB9A | |
| SCHEMBL846514 | 0.74 | TRPV1 (0.68) | TRPV1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL846061 | 0.74 | TRPV1 (1.00) | TRPV1NPC1RAB9A | |
| SCHEMBL847748 | 0.73 | TRPV1 (0.72) | TRPV1MCHR1 | |
| SCHEMBL847641 | 0.72 | TRPV1 (0.98) | TRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |