Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642930 | 1.00 | RXRA (0.36) | RXRARXRBPPARGPPARAKDM4E | |
| SCHEMBL8600527 | 1.00 | RXRA (0.36) | RXRARXRBPPARGPPARAKDM4E | |
| SCHEMBL6642920 | 1.00 | RXRA (0.36) | RXRARXRBPPARGPPARAKDM4E | |
| SCHEMBL8135095 | 0.84 | KDM4E (0.33) | KDM4ELMNATP53 | |
| SCHEMBL8135091 | 0.84 | KDM4E (0.33) | KDM4ELMNATP53 | |
| SCHEMBL6638349 | 0.77 | MAPK1 (0.45) | PPARALMNATP53MAPK1L3MBTL1 | |
| SCHEMBL6638359 | 0.77 | MAPK1 (0.45) | PPARALMNATP53MAPK1L3MBTL1 | |
| SCHEMBL10877592 | 0.71 | ALDH1A1 (0.47) | KDM4ELMNATP53L3MBTL1GAA | |
| SCHEMBL6637459 | 0.70 | TP53 (0.41) | RXRARXRBPPARAKDM4ELMNA | |
| SCHEMBL6637452 | 0.70 | TP53 (0.41) | RXRARXRBPPARAKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824524-A1 | ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE | PHARMACIA & UPJOHN COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |