SCHEMBL8601255

SCHEMBL8601255

Clc1cccc(C(Cl)(Cl)c2ccccc2)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 3/20 0.48
TSHR P16473 5/20 0.46
KCNA3 P22001 2/20 0.38
CYP1A2 P05177 4/20 0.37
LMNA P02545 3/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
HTR2A P28223 2/20 0.37
HTR2C P28335 2/20 0.37
OPRK1 P41145 2/20 0.37
KCNH2 Q12809 2/20 0.37
MAPT P10636 2/20 0.37
ADRA1A P35348 1/20 0.37
SLC22A1 O15245 1/20 0.37
NR1I2 O75469 1/20 0.37
GMNN O75496 1/20 0.37
USP2 O75604 1/20 0.37
TRPM2 O94759 1/20 0.37
ABCB11 O95342 1/20 0.37
EGFR P00533 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6337202 0.85 KCNN4 (0.59) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL11520709 0.83 TSHR (0.41) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL18485454 0.83 KCNN4 (0.48) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL5742924 0.80 KCNN4 (0.46) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL11724522 0.79 TSHR (0.55) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL11625668 0.79 KCNN4 (0.48) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL699760 0.79 KCNN4 (0.59) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL31607641 0.79 KCNN4 (0.59) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL6369696 0.78 CYP3A4 (0.47) KCNN4TSHRKCNA3CYP1A2LMNA
SCHEMBL4101168 0.78 KCNN4 (0.47) KCNN4TSHRKCNA3CYP1A2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113004131-B Preparation method of 2,4, 6-trichlorophenyl substituted acetone 江苏先导药业有限公司 2022-05-13 CN disclosed
CN-113004131-A Preparation method of 2,4, 6-trichlorophenyl substituted acetone 江苏先导药业有限公司 2021-06-22 CN disclosed
WO-2020131678-A1 CLEANSING COMPOSITION AND METHOD LUBRIZOL ADVANCED MATERIALS, INC. (US) 2020-06-25 WO disclosed
WO-2017063848-A1 SANITISING AND DISINFECTING COMPOSITIONS UNILEVER N.V. (NL) 2017-04-20 WO disclosed
CN-1235563-C Soap bar for personal cleansing and process for making same UNILEVER PLC (NL) 2006-01-11 CN disclosed
CN-1438872-A Soap bar for personal cleansing and process for making same UNILEVER PLC (NL) 2003-08-27 CN disclosed
CN-1079663-C Mild shower gel composition comprising fatty alcohol which imparts improved lathering and thickening properties PROCTER & GAMBLE (US) 2002-02-27 CN disclosed
CN-1074277-C Liquid skin cleaning preparation UNILEVER N C (NL) 2001-11-07 CN disclosed
CN-1179095-A Liquid cleaning formulations for skin UNILEVER PLC (NL) 1998-04-15 CN disclosed
EP-0817607-A1 LIQUID CLEANSING FORMULATIONS UNILEVER PLC (GB) 1998-01-14 EP disclosed
WO-1996029049-A1 LIQUID CLEANSING FORMULATIONS UNILEVER PLC (GB) 1996-09-26 WO disclosed
EP-0428081-B1 Method for producing diarylmethanes KUREHA CHEMICAL IND CO LTD (JP) 1994-05-04 EP disclosed
US-5296601-A Reaction of aromatic chloride with carbon monoxide and alcohol NIHON NOHYAKU CO., LTD. (JP) 1994-03-22 US disclosed
EP-0282266-B1 PROCESS FOR PRODUCING CARBOXYLIC ACID AMIDES OR ESTERS NIHON NOHYAKU CO., LTD. (JP) 1992-09-09 EP disclosed
US-5142057-A Reacting an organic chloride with carbon monoxide and amine NIHON NOHYAKU CO., LTD. (JP) 1992-08-25 US disclosed
US-5068481-A Reaction of benzyl chloride with benzene or alkylbenzene in the presence of a zeolite catalyst KUREHA KAGAKU KOGYO K.K. (JP) 1991-11-26 US disclosed
EP-0428081-A1 Method for producing diarylmethanes KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-05-22 EP disclosed
EP-0282266-A2 Process for producing carboxylic acid amides or esters NIHON NOHYAKU CO., LTD. (JP) 1988-09-14 EP disclosed
US-4434246-A Process for preparing ethylene glycol and lower monohydric alcohols from syngas using a novel catalyst system TEXACO INC. (US) 1984-02-28 US disclosed
US-4196148-A AMMONIA, DIAMINE AND POLYMER RECOVERY FORD MOTOR COMPANY (US) 1980-04-01 US disclosed