SCHEMBL860134

SCHEMBL860134

COc1cc(C(=O)ON2C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)C(=O)N(OC(=O)c4cc(OC)c(OC)c(OC)c4)C5=O)cc3C2=O)cc(OC)c1OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
MAPT P10636 4/20 0.42
HDAC3 O15379 2/20 0.41
HDAC4 P56524 2/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC7 Q8WUI4 2/20 0.41
HDAC2 Q92769 2/20 0.41
HDAC10 Q969S8 2/20 0.41
HDAC11 Q96DB2 2/20 0.41
HDAC8 Q9BY41 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
HDAC9 Q9UKV0 2/20 0.41
HDAC5 Q9UQL6 2/20 0.41
POLB P06746 2/20 0.41
KMT2A Q03164 3/20 0.40
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
CYP2C9 P11712 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL860276 0.84 TUBB4A (0.50) ALDH1A1MAPTHDAC3HDAC4HDAC1
SCHEMBL860271 0.83 MAPT (0.46) ALDH1A1MAPTHDAC3HDAC4HDAC1
SCHEMBL860269 0.78 MAPT (0.40) ALDH1A1MAPTHDAC3HDAC4HDAC1
SCHEMBL859516 0.78 ALDH1A1 (0.45) ALDH1A1POLBKMT2ACA12CA1
SCHEMBL859502 0.76 ALDH1A1 (0.54) ALDH1A1MAPTPOLBKMT2ACA12
SCHEMBL859771 0.74 ALDH1A1 (0.48) ALDH1A1MAPTPOLBKMT2ACA1
SCHEMBL860126 0.74 ALDH1A1 (0.45) ALDH1A1MAPTPOLBKMT2ACA12
SCHEMBL859504 0.70 ALDH1A1 (0.47) ALDH1A1MAPTPOLBCA1CA2
SCHEMBL13814012 0.67 ALDH1A1 (0.43) ALDH1A1MAPTPOLBKMT2ACA12
SCHEMBL11756900 0.67 ALDH1A1 (0.49) ALDH1A1MAPTPOLBKMT2ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2100731-B1 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORP (JP) 2012-06-20 EP disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-8142983-B2 Lithographic printing plate precursor and method of lithographic printing FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
US-20090233229-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING FUJIFILM CORPORATION (JP) 2009-09-17 US disclosed
EP-2100731-A2 Lithographic printing plate precursor and method of lithographic printing Fujifilm Corporation (JP) 2009-09-16 EP disclosed