Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.64 |
| ▸ | HTR6 | P50406 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553465 | 0.88 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| Hydrochloric Acid SCHEMBL8601366 | 0.87 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL1554312 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL22670361 | 0.79 | HTR6 (0.55) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL1553409 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1553735 | 0.79 | PDE4D (0.70) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL11976615 | 0.78 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL8604227 | 0.78 | SLC22A12 (0.55) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL18858718 | 0.76 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL11975851 | 0.76 | KDM4E (0.54) | PDE4APDE4BPDE4CPDE4DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |