Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.37 |
| ▸ | PTGIR | P43119 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601664 | 1.00 | HSP90AA1 (0.43) | HSP90AA1MAPK1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8602824 | 0.84 | PTGIR (0.50) | HSP90AA1MAPK1SMN1; SMN2PTGIR | |
| SCHEMBL8602826 | 0.84 | PTGIR (0.50) | HSP90AA1MAPK1SMN1; SMN2PTGIR | |
| SCHEMBL8601668 | 0.80 | HSP90AA1 (0.44) | HSP90AA1MAPK1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8626804 | 0.73 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDTDP1MAPT | |
| SCHEMBL8600090 | 0.73 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDTDP1MAPT | |
| SCHEMBL8599525 | 0.73 | PTGIR (0.48) | HSP90AA1MAPK1SMN1; SMN2KDM4EPTGIR | |
| SCHEMBL8599522 | 0.73 | PTGIR (0.48) | HSP90AA1MAPK1SMN1; SMN2KDM4EPTGIR | |
| SCHEMBL10358272 | 0.73 | TBXA2R (0.50) | MTNR1AMTNR1BPTGIRMAPTCYP1A2 | |
| SCHEMBL8602989 | 0.72 | PTGIR (0.42) | ALDH1A1KDM4EHPGDTDP1PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657422-B1 | Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists | ONO PHARMACEUTICAL CO (JP) | 1998-06-10 | — | — | EP | claimed |
| US-5723493-A | PROSTAGLANDIN DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-03-03 | — | — | US | claimed |
| EP-0657422-A1 | Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-06-14 | — | — | EP | claimed |
| US-5723493-A | PROSTAGLANDIN DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-03-03 | — | — | US | disclosed |
| US-5624959-A | INHIBITING UTERINE CONTRACTIONS, PROSTAGLANDIN ANTAGONIST OR AGONIST, ANALGESICS AND ANTISECRETORY AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| EP-0657422-A1 | Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-06-14 | — | — | EP | disclosed |