Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601707 | 1.00 | MMP13 (0.49) | MMP13CA1CA2ACHEHSD11B1 | |
| SCHEMBL7862144 | 0.86 | MMP13 (0.48) | MMP13CA1CA2ACHEHSD11B1 | |
| Hydrochloric Acid SCHEMBL7862140 | 0.85 | MMP13 (0.47) | MMP13CA1CA2ACHEHSD11B1 | |
| SCHEMBL8440143 | 0.83 | NPC1 (0.55) | MMP13CA1CA2ACHEHSD11B1 | |
| SCHEMBL7869903 | 0.83 | MMP13 (0.57) | MMP13CA1CA2ACHEMMP2 | |
| SCHEMBL8521710 | 0.81 | HTT (0.58) | MMP13HSD11B1HTTNPSR1MMP2 | |
| SCHEMBL27410647 | 0.80 | LDHA (0.55) | CA1CA2ACHEALDH1A1ATM | |
| SCHEMBL6381667 | 0.79 | NPC1 (0.56) | MMP13CA1CA2ACHEHSD11B1 | |
| SCHEMBL7868834 | 0.78 | MMP13 (0.61) | MMP13CA1CA2ACHEATM | |
| SCHEMBL7874114 | 0.77 | MMP13 (0.57) | MMP13CA1CA2ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966438-A1 | N-HYDROXY-BETA-SULFONYL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | PFIZER INC. (US) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998034915-A1 | N-HYDROXY-BETA-SULFONYL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |