Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588090 | 0.86 | GABRG2 (0.47) | GABRG2GABRB3GABRA5GABRA3HRH4 | |
| SCHEMBL1588228 | 0.85 | HRH4 (0.56) | GABRG2GABRB3GABRA5GABRA3HRH4 | |
| SCHEMBL848992 | 0.80 | HRH4 (0.65) | GABRG2GABRB3GABRA5GABRA3HRH4 | |
| SCHEMBL846641 | 0.80 | HRH4 (0.53) | GABRG2GABRB3GABRA5GABRA3HRH4 | |
| SCHEMBL848112 | 0.79 | HRH4 (0.70) | HRH4 | |
| SCHEMBL846007 | 0.78 | ACHE (0.54) | GABRG2GABRB3GABRA5GABRA3HRH4 | |
| SCHEMBL1588725 | 0.72 | HRH4 (0.48) | HRH4ALDH1A1HPGD | |
| SCHEMBL1588917 | 0.70 | HRH4 (0.46) | HRH4ACHEHRH1CHRNB4CHRNA3 | |
| SCHEMBL1588872 | 0.70 | HRH4 (0.51) | HRH4HPGD | |
| SCHEMBL861161 | 0.70 | HRH4 (0.48) | GABRG2GABRB3GABRA5GABRA3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524363-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | claimed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | claimed |