Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.41 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.41 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459669 | 0.81 | ALDH1A1 (0.47) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL21384494 | 0.81 | HTR2A (0.61) | ALDH1A1KDM4EHTR2AHTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL30069210 | 0.80 | HTR2A (0.59) | ALDH1A1KDM4EHTR2AHTR2CSLC6A4 | |
| SCHEMBL28265996 | 0.77 | GAA (0.54) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15275375 | 0.77 | GAA (0.50) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14659450 | 0.77 | CYP1A2 (0.47) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2096941 | 0.77 | CYP1A2 (0.47) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5067333 | 0.77 | KEAP1 (0.55) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2096944 | 0.77 | PIM1 (0.50) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24008433 | 0.77 | EPHX2 (0.43) | KEAP1MAPK1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |