Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.73 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12082439 | 0.84 | ALOX5 (0.69) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL10758216 | 0.84 | ALOX5 (1.00) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| Fuberidazole SCHEMBL8817074 | 0.81 | ALOX5 (0.65) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| Fuberidazole SCHEMBL29603252 | 0.81 | ALOX5 (0.65) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| Fuberidazole SCHEMBL23174 | 0.81 | ALOX5 (0.65) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL20550741 | 0.81 | ALOX5 (0.64) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL16497674 | 0.80 | PKN1 (0.51) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL10768929 | 0.80 | GPR119 (0.64) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL20550456 | 0.80 | ALOX5 (0.63) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL10755191 | 0.79 | CHEK1 (1.00) | ALOX5EPHX2CHEK1LIMK1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824698-A | STAPHYLOCOCCUS, ENTEROCOCCUS OR HELIOBACTER | HOFFMAN-LA ROCHE INC. (US) | 1998-10-20 | — | — | US | claimed |
| US-5824698-A | STAPHYLOCOCCUS, ENTEROCOCCUS OR HELIOBACTER | HOFFMAN-LA ROCHE INC. (US) | 1998-10-20 | — | — | US | disclosed |