Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601356 | 0.76 | MAPK14 (0.55) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL8606320 | 0.75 | RAF1 (0.49) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2029325 | 0.68 | MAPK14 (0.56) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5848398 | 0.68 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6469559 | 0.67 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2649589 | 0.66 | MAPK13 (0.90) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL699188 | 0.65 | KDM4E (0.45) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2648428 | 0.65 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5452477 | 0.65 | RAF1 (0.50) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5216102 | 0.64 | MAPK14 (0.61) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012876-A9 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | — | 1997-09-18 | — | — | WO | claimed |
| US-5717100-A | Substituted imidazoles having anti-cancer and cytokine inhibitory activity | MERCK & CO., INC. (US) | 1998-02-10 | — | — | US | disclosed |