Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 2/20 | 0.55 |
| ▸ | GCGR | P47871 | 10/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | FRK | P42685 | 2/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045129 | 0.81 | GPR55 (0.43) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL8605486 | 0.76 | MAPK13 (0.46) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5258469 | 0.73 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL14519418 | 0.73 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL699188 | 0.72 | KDM4E (0.45) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL8606320 | 0.72 | RAF1 (0.49) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL25220966 | 0.71 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6423292 | 0.71 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4434902 | 0.71 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6626583 | 0.71 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717100-A | Substituted imidazoles having anti-cancer and cytokine inhibitory activity | MERCK & CO., INC. (US) | 1998-02-10 | — | — | US | disclosed |