Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602193 | 0.97 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8603781 | 0.88 | MAPT (0.42) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8572042 | 0.86 | PRMT5 (0.48) | MAPTMAPK1MAOBMAOATOP1 | |
| SCHEMBL8571345 | 0.86 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8576284 | 0.86 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8601582 | 0.86 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8671822 | 0.86 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8569752 | 0.85 | MAPT (0.40) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8571260 | 0.85 | MAPT (0.40) | MAPTMAPK1MAOBMAOATOP1 | |
| SCHEMBL8598873 | 0.84 | ADORA3 (0.40) | MAPTMAPK1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |