Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 12/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8606141 | 0.86 | AKR1C3 (0.47) | AKR1C3AKR1C2PTGS1AKR1C4POLB | |
| SCHEMBL8605079 | 0.84 | PTGS1 (0.46) | AKR1C3AKR1C2PTGS1AKR1C4POLB | |
| SCHEMBL8604032 | 0.81 | AKR1C3 (0.47) | AKR1C3AKR1C2PTGS1AKR1C4ABCB1 | |
| SCHEMBL8606260 | 0.78 | AKR1C3 (0.83) | AKR1C3AKR1C2PTGS1AKR1C4ABCB1 | |
| SCHEMBL21578435 | 0.76 | AKR1C3 (0.70) | AKR1C3AKR1C2PTGS1AKR1C4ABCB1 | |
| SCHEMBL8604631 | 0.76 | PTGS1 (0.41) | AKR1C3AKR1C2PTGS1AKR1C4ABCB1 | |
| SCHEMBL8603649 | 0.76 | ABCB1 (0.65) | AKR1C3AKR1C2PTGS1AKR1C4ABCB1 | |
| SCHEMBL3241798 | 0.76 | ABCB11 (0.46) | POLBKMT2AMAPTHPGD | |
| SCHEMBL6271277 | 0.75 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS1AKR1C4AR | |
| SCHEMBL8602252 | 0.75 | KMT2A (0.48) | AKR1C3AKR1C2PTGS1AKR1C4ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721347-A | Esters and amides of substituted pyrrole acetic acids | CELL PATHWAYS, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0485157-A2 | Esters and amides of substituted pyrrole acetic acids | FGN, INC. (US) | 1992-05-13 | — | — | EP | disclosed |