SCHEMBL8606571

SCHEMBL8606571

O=C(c1ccccc1Cl)c1cccc(Cl)c1Cl

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.63
CES2 O00748 1/20 0.58
CES1 P23141 1/20 0.58
ALDH1A1 P00352 2/20 0.56
RECQL P46063 1/20 0.55
P2RX7 Q99572 1/20 0.53
POLB P06746 1/20 0.52
ERCC5 P28715 1/20 0.50
FEN1 P39748 1/20 0.50
PKM P14618 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
KMT2A Q03164 2/20 0.49
RORB Q92753 2/20 0.47
RORC P51449 1/20 0.47
CYP2C9 P11712 1/20 0.47
JAK2 O60674 1/20 0.46
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
TAS1R2 Q8TE23 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9134364 0.93 TSHR (0.65) TSHRCES2CES1ALDH1A1RECQL
SCHEMBL7032023 0.93 TSHR (0.71) TSHRCES2CES1ALDH1A1RECQL
SCHEMBL50416 0.89 CES2 (0.71) TSHRCES2CES1ALDH1A1RECQL
SCHEMBL29399311 0.89 CES2 (0.71) TSHRCES2CES1ALDH1A1RECQL
SCHEMBL3444846 0.86 CES2 (0.68) TSHRCES2CES1ALDH1A1RECQL
SCHEMBL6143391 0.86 CES2 (0.52) TSHRCES2CES1ALDH1A1RECQL
SCHEMBL30403796 0.83 TSHR (0.64) TSHRCES2CES1ALDH1A1P2RX7
SCHEMBL334531 0.83 TSHR (0.64) TSHRCES2CES1ALDH1A1P2RX7
SCHEMBL31502517 0.82 TSHR (0.62) TSHRCES2CES1ALDH1A1P2RX7
SCHEMBL7931237 0.81 CES2 (0.56) TSHRCES2CES1ALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113227902-B Liquid photopolymer resin composition for flexographic printing 麦克德米德图像方案股份有限公司 2024-09-27 CN disclosed
US-5750631-A CURABLE EPOXIDIZED PHENOLIC RESIN CONTAINING CHLORINE AND/OR BROMINE; FIREPROOFING, BY-PRODUCT INHIBITION SHELL OIL COMPANY (US) 1998-05-12 US disclosed
EP-0293115-B1 Melt-stable poly(arylene thiotherketone) and production process thereof KUREHA CHEMICAL IND CO LTD (JP) 1997-09-17 EP disclosed
US-5378772-A Copolymerization of poly(arylene thioetherketoneketones) KUREHA KAGAKU KOGYO K.K. (JP) 1995-01-03 US disclosed
US-5378771-A Sulfiding dihalobenzene and bis(halobenzoyl)benzene in two steps to copolymerize poly(arylene thioetherketoneketones) KUREHA KAGAKU KOGYO K.K.K. (JP) 1995-01-03 US disclosed
US-5248743-A Polythioethers KUREHA KAGAKU KOGYO K.K. (JP) 1993-09-28 US disclosed
US-5153279-A Heat resistance, melt processability KUREHA KAGAKU KOGYO K.K. (JP) 1992-10-06 US disclosed
US-5153278-A Heat resistance, workability; materials handling; molding materials; films KUREHA KAGAKU KOGYO K.K. (JP) 1992-10-06 US disclosed
US-5153264-A Heating dihalo aromatic compound and alkali metal sulfide, mixing with dihalo aromatic carbonyl compound; organic amide and water solvent KUREHA KAGAKU KOGYO K.K. (JP) 1992-10-06 US disclosed
US-5120808-A Melt processability, heat resistance polyether ketone polymers KUREHA KAGAKU KOGYO K.K. (JP) 1992-06-09 US disclosed
EP-0435674-A2 High-heat-resistant, crystalline block copolymers and production process thereof KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-07-03 EP disclosed
EP-0369620-A2 Poly(arylene thioether)block copolymer and production process thereof KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1990-05-23 EP disclosed
US-4895925-A HEAT RESISTANT MOLDING MATERIAL KUREHA KAGAKU KOGYO K.K. (JP) 1990-01-23 US disclosed
US-4886871-A REACTING ALKALI METAL SULFIDE AND DIHALOGENATED COMPOUNDS KUREHA KAGAKU KOGYO K. K. (JP) 1989-12-12 US disclosed
EP-0293115-A2 Melt-stable poly(arylene thiotherketone) and production process thereof KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-11-30 EP disclosed
EP-0000502-A1 Process for preparing butyl-p-benzoylbenzoates STAUFFER CHEMICAL COMPANY (US) 1979-02-07 EP disclosed
US-3956324-A THERMOPLASTIC POLYMER CIBA-GEIGY CORPORATION (US) 1976-05-11 US disclosed