Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PGK2 | P07205 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8607629 | 0.82 | NR1H3 (0.44) | SCN2ANR1H3NR1H2ALPLGRM5 | |
| SCHEMBL9753503 | 0.81 | PGK1 (0.41) | ALPLGRM5ARPGK1PGK2 | |
| SCHEMBL8607339 | 0.76 | SCN2A (0.48) | SCN2ANR1H3NR1H2ALPLGRM5 | |
| SCHEMBL11615606 | 0.70 | NR1H3 (0.61) | SCN2ANR1H3NR1H2GRM5KDM4E | |
| SCHEMBL9753555 | 0.70 | PGK1 (0.41) | RAB9APGK1PGK2TDP1NPC1 | |
| Butane SCHEMBL8606470 | 0.68 | NR1H3 (0.38) | SCN2ANR1H3NR1H2ALPLGRM5 | |
| SCHEMBL9753562 | 0.68 | KDM4E (0.41) | GRM5RAB9APGK1PGK2KDM4E | |
| SCHEMBL9753803 | 0.67 | SMN1; SMN2 (0.37) | ALPLARPGK1PGK2KDM4E | |
| SCHEMBL4728822 | 0.65 | NR1H3 (0.67) | SCN2ANR1H3NR1H2GRM5CYP1A2 | |
| SCHEMBL30758624 | 0.65 | NR1H3 (0.67) | SCN2ANR1H3NR1H2GRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |