SCHEMBL8607752

SCHEMBL8607752

Cc1n[nH]c(-c2ccc(S(N)(=O)=O)cc2)c1-c1ccccc1-c1ccc(F)cc1

nearest known ligand 0.62

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 16/20 0.62
PTGS1 P23219 10/20 0.62
CA12 O43570 2/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA9 Q16790 2/20 0.48
CHRNA7 P36544 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5698536 0.79 PTGS2 (1.00) PTGS2PTGS1CA12CA1CA2
SCHEMBL6621394 0.75 PTGS2 (0.53) PTGS2PTGS1CA12CA1CA2
SCHEMBL8607523 0.74 PTGS2 (0.46) PTGS2PTGS1CA12CA1CA2
SCHEMBL8953573 0.73 CA2 (0.44) PTGS2PTGS1CA12CA1CA2
SCHEMBL8953709 0.71 CA1 (0.47) PTGS2PTGS1CA12CA1CA2
SCHEMBL6725526 0.70 CA12 (0.73) PTGS2PTGS1CA12CA1CA2
SCHEMBL7780654 0.69 PTGS2 (0.62) PTGS2PTGS1
SCHEMBL6725513 0.69 PTGS2 (0.77) PTGS2PTGS1CA12CA1CA2
SCHEMBL15730256 0.69 CA2 (0.62) PTGS2PTGS1CA12CA1CA2
SCHEMBL8764358 0.69 PTGS2 (0.52) PTGS2PTGS1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0731794-A1 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS SEARLE & CO (US) 1996-09-18 EP claimed
WO-1995015317-A1 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS G.D. SEARLE & CO. (US) 1995-06-08 WO claimed
EP-0830133-A1 THERAPEUTIC COMPOSITION FOR ARTHRITIS Takeda Chemical Industries, Ltd. (JP) 1998-03-25 EP disclosed
WO-1996033717-A1 THERAPEUTIC COMPOSITION FOR ARTHRITIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-10-31 WO disclosed
EP-0731794-A1 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS SEARLE & CO (US) 1996-09-18 EP disclosed
WO-1995015317-A1 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS G.D. SEARLE & CO. (US) 1995-06-08 WO disclosed