Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 2/20 | 0.52 |
| ▸ | HTRA2 | O43464 | 8/20 | 0.49 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731441 | 0.92 | ALB (0.54) | ALBHTRA2HTRA1 | |
| SCHEMBL861480 | 0.87 | PTGS2 (0.56) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL860836 | 0.86 | PTGS2 (0.58) | FOLH1HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL861064 | 0.83 | PTGS2 (0.57) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL861487 | 0.83 | PTGS2 (0.51) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL16181473 | 0.79 | PTGS2 (0.53) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL878470 | 0.79 | PTGS2 (0.55) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL860837 | 0.78 | PTGS2 (0.50) | HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL860839 | 0.77 | CNR2 (0.56) | ALB | |
| SCHEMBL10148093 | 0.77 | ALB (0.49) | ALBHTRA2HTRA1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143302-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143302-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100254910-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100254910-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100254910-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | PTGS2, PTGES2, PTGER2 | ALB 1282/4885HTRA2 65/4885HTRA1 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.