Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 known ✓ | P29474 | 2/20 | 0.58 |
| ▸ | NOS1 known ✓ | P29475 | 2/20 | 0.58 |
| ▸ | NOS2 known ✓ | P35228 | 2/20 | 0.58 |
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.92 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.92 |
| ▸ | ALPI | P09923 | 1/20 | 0.92 |
| ▸ | PKM | P14618 | 1/20 | 0.92 |
| ▸ | XIAP | P98170 | 1/20 | 0.92 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.65 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.65 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.65 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL8609032 | 1.00 | SLC7A5 (0.92) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL28298770 | 0.96 | SLC7A5 (0.92) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL28298768 | 0.96 | SLC7A5 (0.92) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL28570385 | 0.96 | SLC7A5 (0.92) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL28570383 | 0.96 | SLC7A5 (0.92) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL23159186 | 0.96 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| D-Phenylalanine SCHEMBL837632 | 0.96 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL16398197 | 0.96 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL385804 | 0.96 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL8118 | 0.96 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468063-B1 | A one-pot process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride | NUTRASWEET CO (US) | 1996-06-05 | — | — | EP | claimed |
| US-5476961-A | Formylating L-aspartic acid, coupling with L-phenylalanine in the presence of acetic acid, deformylating, removing acid residues, esterifying, forming salt | THE NUTRASWEET COMPANY (US) | 1995-12-19 | — | — | US | claimed |
| CN-1091952-A | Cosmetic composition | UNILEVER NV (NL) | 1994-09-14 | — | — | CN | claimed |
| EP-0468063-A1 | A one-pot process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride | THE NUTRASWEET COMPANY (US) | 1992-01-29 | — | — | EP | claimed |
| WO-1992000953-A1 | A ONE-POT PROCESS FOR THE PREPARATION OF ALPHA-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE | THE NUTRASWEET COMPANY (US) | 1992-01-23 | — | — | WO | claimed |
| US-5723576-A | POLYPEPTIDES FOR ENZYME INHIBITORS AND HIRUNDIN | DEVELOPMENT BIOTECHNOLOGICAL PROCESSES S.N.C. (IT) | 1998-03-03 | — | — | US | disclosed |
| CN-1091952-A | Cosmetic composition | UNILEVER NV (NL) | 1994-09-14 | — | — | CN | disclosed |