D-Phenylalanine

D-Phenylalanine

SCHEMBL837632

N[C@H](Cc1ccccc1)C(=O)O.N[C@H](Cc1ccccc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 1.00
PTGS1 P23219 2/20 1.00
ALPI P09923 1/20 1.00
PKM P14618 1/20 1.00
XIAP P98170 1/20 1.00
SLC1A3 P43003 2/20 0.69
SLC1A2 P43004 2/20 0.69
SLC1A1 P43005 2/20 0.69
SLC15A1 P46059 1/20 0.63
CYP1A2 P05177 1/20 0.61
LTA4H P09960 1/20 0.59
GRIA2 P42262 1/20 0.59
KDM4E B2RXH2 1/20 0.58
USP2 O75604 1/20 0.58
EGFR P00533 1/20 0.58
LCK P06239 1/20 0.58
FYN P06241 1/20 0.58
ADORA3 P0DMS8 1/20 0.58
ALOX15 P16050 1/20 0.58
HTR2A P28223 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Phenylalanine SCHEMBL15671104 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL16398196 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL1449124 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL16398197 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL385804 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL8119 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL23159186 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL43671 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL8118 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL1331985 1.00 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118085029-A Enzyme-responsive controlled-release antibiotic prodrug, and preparation method and application thereof 国家纳米科学中心 2024-05-28 CN claimed
US-20160159832-A1 SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2016-06-09 US claimed
WO-2015013322-A1 SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2015-01-29 WO claimed
US-20110275648-A1 FLURBIPROFEN ANALOGS AND METHODS OF USE IN TREATING CANCER THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2011-11-10 US claimed
WO-2011106721-A1 FLURBIPROFEN ANALOGS AND METHODS OF USE IN TREATING CANCER THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2011-09-01 WO claimed
EP-1053249-A2 PEPTIDE INHIBITORS OF THE SERINE PROTEASE ACTIVITY ASSOCIATED TO THE NS3 PROTEIN OF HCV, RELEVANT USES AND PROCESS OF PRODUCTION Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) 2000-11-22 EP claimed
WO-1999038888-A2 PEPTIDE INHIBITORS OF THE SERINE PROTEASE ACTIVITY ASSOCIATED TO THE NS3 PROTEIN OF HCV, RELEVANT USES AND PROCESS OF PRODUCTION ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE (IT) 1999-08-05 WO claimed
WO-1993015042-A1 PROCESS FOR THE PREPARATION OF D(-) AND L(+)-3,3-DIPHENYLALANINE AND D(-) AND L(+)-SUBSTITUTED 3,3-DIPHENYLALANINES AND DERIVATIVES THEREOF WARNER-LAMBERT COMPANY (US) 1993-08-05 WO claimed
US-5198548-A Chemical intermediates for angiotensins WARNER-LAMBERT COMPANY (US) 1993-03-30 US claimed
CN-118085029-A Enzyme-responsive controlled-release antibiotic prodrug, and preparation method and application thereof 国家纳米科学中心 2024-05-28 CN disclosed
US-20230338546-A1 ORAL FORMULATIONS OF KAPPA OPIOID RECEPTOR AGONISTS CARA THERAPEUTICS INC (US) 2023-10-26 US disclosed
US-11684674-B2 Oral formulations of kappa opioid receptor agonists CARA THERAPEUTICS, INC. (US) 2023-06-27 US disclosed
CN-115244067-A Synthetic antimicrobial peptides AJK生物制药有限责任公司 2022-10-25 CN disclosed
US-20220289794-A1 SYNTHETIC ANTIMICROBIAL PEPTIDES AJK BIOPHARMACEUTICAL LLC (US) 2022-09-15 US disclosed
WO-1993021176-A1 NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF WARNER-LAMBERT COMPANY (US) 1993-10-28 WO disclosed
WO-1993015042-A1 PROCESS FOR THE PREPARATION OF D(-) AND L(+)-3,3-DIPHENYLALANINE AND D(-) AND L(+)-SUBSTITUTED 3,3-DIPHENYLALANINES AND DERIVATIVES THEREOF WARNER-LAMBERT COMPANY (US) 1993-08-05 WO disclosed
WO-1993015042-A1 PROCESS FOR THE PREPARATION OF D(-) AND L(+)-3,3-DIPHENYLALANINE AND D(-) AND L(+)-SUBSTITUTED 3,3-DIPHENYLALANINES AND DERIVATIVES THEREOF WARNER-LAMBERT COMPANY (US) 1993-08-05 WO disclosed
US-5198548-A Chemical intermediates for angiotensins WARNER-LAMBERT COMPANY (US) 1993-03-30 US disclosed
US-5198548-A Chemical intermediates for angiotensins WARNER-LAMBERT COMPANY (US) 1993-03-30 US disclosed
US-5198548-A Chemical intermediates for angiotensins WARNER-LAMBERT COMPANY (US) 1993-03-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160159832-A1 SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER BCL3, MYLK2, BCL2L13 SLC7A5 4177/4885PTGS1 2512/4885ALPI 882/4885
US-20230338546-A1 ORAL FORMULATIONS OF KAPPA OPIOID RECEPTOR AGONISTS OPRK1, OPRL1, OGFR SLC7A5 480/4885PTGS1 469/4885ALPI 634/4885
US-20220289794-A1 SYNTHETIC ANTIMICROBIAL PEPTIDES VIP, HM13, NGLY1 SLC7A5 1411/4885PTGS1 4504/4885ALPI 3137/4885
US-20110275648-A1 FLURBIPROFEN ANALOGS AND METHODS OF USE IN TREATING CANCER HCAR1, AADAC, AADAT SLC7A5 553/4885PTGS1 57/4885ALPI 557/4885
US-11684674-B2 Oral formulations of kappa opioid receptor agonists OPRK1, OPRL1, OGFR SLC7A5 480/4885PTGS1 469/4885ALPI 634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.