SCHEMBL8609337

SCHEMBL8609337

O=C1Oc2ccccc2C2CC=NCC12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
ATM Q13315 1/20 0.33
HTR2A P28223 5/20 0.32
HTR2C P28335 5/20 0.32
HRH1 P35367 3/20 0.32
CHRM2 P08172 1/20 0.32
HTR1A P08908 1/20 0.32
ADRA2A P08913 1/20 0.32
DRD2 P14416 1/20 0.32
GABRA1 P14867 1/20 0.32
ADRA2B P18089 1/20 0.32
ADRA2C P18825 1/20 0.32
DRD1 P21728 1/20 0.32
DRD4 P21917 1/20 0.32
SLC6A2 P23975 1/20 0.32
ADRA1D P25100 1/20 0.32
SLC6A4 P31645 1/20 0.32
ADRA1A P35348 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14135291 0.74 MAOA (0.42) CYP2C9MAOAMAOBATMHTR2A
SCHEMBL30883178 0.74 MAOA (0.42) CYP2C9MAOAMAOBATMHTR2A
SCHEMBL2228109 0.72 ESR1 (0.34)
SCHEMBL16257251 0.71 STS (0.50) CYP2C9MAOAMAOBATMHTR2A
SCHEMBL16198062 0.70 DRD2 (0.44) DRD2DRD3HTR2B
SCHEMBL20785351 0.68 MAOA (0.46) CYP2C9MAOAMAOBATMGRM1
SCHEMBL20785353 0.68 MAOA (0.46) CYP2C9MAOAMAOBATMGRM1
SCHEMBL20785352 0.68 MAOA (0.46) CYP2C9MAOAMAOBATMGRM1
SCHEMBL20785354 0.68 MAOA (0.46) CYP2C9MAOAMAOBATMGRM1
SCHEMBL16785724 0.68 MAOA (0.46) CYP2C9MAOAMAOBATMGRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2958924-B1 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) BRISTOL MYERS SQUIBB CO (US) 2016-12-28 EP disclosed
US-5760050-A SCHIZOPHRENIA WARNER-LAMBERT COMPANY (US) 1998-06-02 US disclosed