SCHEMBL8610259

SCHEMBL8610259

CSc1ncnc2c1ncn2[C@@H]1O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H](OC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H]1F

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TYMP P19971 11/20 0.54
SLC29A1 Q99808 4/20 0.47
TP53 P04637 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ADORA1 P30542 2/20 0.47
NT5E P21589 1/20 0.44
STAT6 P42226 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8610263 1.00 TYMP (0.54) TYMPSLC29A1TP53SMN1; SMN2ADORA1
SCHEMBL8610799 0.90 TYMP (0.63) TYMPSLC29A1TP53SMN1; SMN2ADORA1
SCHEMBL8612341 0.89 TYMP (0.63) TYMPSLC29A1TP53SMN1; SMN2ADORA1
SCHEMBL8615093 0.88 TYMP (0.46) TYMPADORA1NT5E
SCHEMBL8615088 0.88 TYMP (0.46) TYMPADORA1NT5E
SCHEMBL8612951 0.88 TYMP (0.71) TYMPSLC29A1ADORA1NT5E
SCHEMBL8612807 0.88 TYMP (0.58) TYMPSLC29A1ADORA1NT5E
SCHEMBL8612956 0.88 TYMP (0.71) TYMPSLC29A1ADORA1NT5E
SCHEMBL8614637 0.88 TYMP (0.56) TYMPSLC29A1ADORA1NT5E
SCHEMBL8611227 0.87 TYMP (0.45) TYMPSLC29A1ADORA1NT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750675-A 2'-\"up\" fluorinated 2'-deoxy-arabinofuranosylpurines SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1998-05-12 US claimed