Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614094 | 0.93 | MEN1 (0.69) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL8615117 | 0.91 | MAPT (0.66) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL8609331 | 0.83 | MAPT (0.66) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL8645443 | 0.83 | ABCB1 (0.73) | ABCB1 | |
| SCHEMBL9410209 | 0.81 | MAPT (1.00) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL8615289 | 0.81 | MAPT (0.63) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL8611715 | 0.81 | HSP90AB1 (0.58) | MEN1KMT2AMAPTTP53ABCB1 | |
| Hydrochloric Acid SCHEMBL9410218 | 0.80 | MAPT (0.98) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL8609924 | 0.80 | MAPT (0.62) | MEN1KMT2AMAPTTP53ABCB1 | |
| SCHEMBL11194101 | 0.80 | ABCB1 (0.66) | MEN1KMT2AABCB1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833639-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-08 | — | — | EP | disclosed |
| US-5614526-A | IN TREATING DISORDERS OF THE DOPAMINE SYSTEM | HOFFMANN-LA ROCHE INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996041630-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-27 | — | — | WO | disclosed |