Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 11/20 | 0.79 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9009939 | 1.00 | VDR (0.79) | VDRCYP24A1 | |
| SCHEMBL9010586 | 1.00 | VDR (0.79) | VDRCYP24A1 | |
| SCHEMBL19601388 | 1.00 | VDR (0.79) | VDRCYP24A1 | |
| SCHEMBL13665667 | 1.00 | VDR (0.79) | VDRCYP24A1 | |
| SCHEMBL12371707 | 0.95 | CYP24A1 (0.77) | VDRCYP24A1 | |
| SCHEMBL12641460 | 0.95 | CYP24A1 (0.77) | VDRCYP24A1 | |
| SCHEMBL14802244 | 0.95 | CYP24A1 (0.77) | VDRCYP24A1 | |
| SCHEMBL12190408 | 0.95 | CYP24A1 (0.77) | VDRCYP24A1 | |
| SCHEMBL22422513 | 0.95 | CYP24A1 (0.77) | VDRCYP24A1 | |
| SCHEMBL9070738 | 0.94 | VDR (0.71) | VDRCYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170326159-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RES FOUND (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170326159-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RES FOUND (US) | 2017-11-16 | — | — | US | disclosed |
| EP-2101727-B1 | COMPOSITIONS FOR USE TO TOPICALLY TREAT ACNE BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RES FOUND (US) | 2017-11-08 | — | — | EP | disclosed |
| US-20160235770-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2016-08-18 | — | — | US | disclosed |
| US-20160235770-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2016-08-18 | — | — | US | disclosed |
| US-9339509-B2 | Methods of use to orally and topically treat acne and other skin conditions by administering a 19-nor containing vitamin D analog with or without a retinoid | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-05-17 | — | — | US | disclosed |
| US-9339509-B2 | Methods of use to orally and topically treat acne and other skin conditions by administering a 19-nor containing vitamin D analog with or without a retinoid | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-05-17 | — | — | US | disclosed |
| US-20140018332-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-01-16 | — | — | US | disclosed |
| US-20140018332-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-01-16 | — | — | US | disclosed |
| EP-2591769-A2 | Compounds, compositions, kits and methods of use to topically treat acne and other skin conditions by administering a 19-nor containing vitamin D analog. | Wisconsin Alumni Research Foundation (US) | 2013-05-15 | — | — | EP | disclosed |
| US-8404667-B2 | 2-methylene-19-nor-20(S)-1 alpha -hydroxy-bishomopregnacalciferol; 13-cis-retinoic acid activator; acne, psoriasis, ichthyosis, photoaging, photodamaged skin, skin cancer | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-8143238-B2 | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin D compound | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110195941-A1 | Methods of Use To Orally and Topically Treat Acne and Other Skin Conditions By Administering a 19-NOR Containing Vitamin D Analog With or Without a Retinoid | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2011-08-11 | — | — | US | disclosed |
| US-20110195941-A1 | Methods of Use To Orally and Topically Treat Acne and Other Skin Conditions By Administering a 19-NOR Containing Vitamin D Analog With or Without a Retinoid | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2011-08-11 | — | — | US | disclosed |
| WO-2009111695-A8 | METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009111695-A1 | METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-11 | — | — | WO | disclosed |
| US-20090227545-A1 | METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2009-09-10 | — | — | US | disclosed |
| US-20080261925-A1 | COMPOUNDS, COMPOSITIONS, KITS AND METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-10-23 | — | — | US | disclosed |
| US-20080261925-A1 | COMPOUNDS, COMPOSITIONS, KITS AND METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-10-23 | — | — | US | disclosed |
| WO-2008083370-A2 | COMPOUNDS, COMPOSTIONS, KITS AND METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINSTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A REYINOID | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261925-A1 | COMPOUNDS, COMPOSITIONS, KITS AND METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | CYP2R1, CYP24A1, VDR | VDR 3/4885CYP24A1 2/4885 |
| US-20170326159-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | CYP24A1, CYP2R1, VDR | VDR 3/4885CYP24A1 1/4885 |
| US-20140018332-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | CYP24A1, CYP2R1, VDR | VDR 3/4885CYP24A1 1/4885 |
| US-20110195941-A1 | Methods of Use To Orally and Topically Treat Acne and Other Skin Conditions By Administering a 19-NOR Containing Vitamin D Analog With or Without a Retinoid | CYP24A1, CYP2R1, VDR | VDR 3/4885CYP24A1 1/4885 |
| US-20160235770-A1 | METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID | CYP24A1, CYP2R1, VDR | VDR 3/4885CYP24A1 1/4885 |
| US-20090227545-A1 | METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND | CYP24A1, CYP2R1, VDR | VDR 3/4885CYP24A1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.