SCHEMBL8610641

SCHEMBL8610641

CCC(CC)CNc1ccc(Cl)cc1N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.40
ALDH1A1 P00352 4/20 0.39
TSHR P16473 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
ALOX15 P16050 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
TP53 P04637 1/20 0.38
HDAC1 Q13547 1/20 0.38
GAA P10253 3/20 0.37
HPGD P15428 2/20 0.37
MAPT P10636 2/20 0.37
KDM4E B2RXH2 2/20 0.37
THRB P10828 1/20 0.37
HTT P42858 1/20 0.37
GFER P55789 1/20 0.37
PLEC Q15149 1/20 0.37
ALOX12 P18054 1/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3787955 0.80 ALDH1A1 (0.54) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL21799996 0.75 MAPT (0.39) CYP3A4ALDH1A1SMN1; SMN2ALOX15TDP1
SCHEMBL29922652 0.75 MAPT (0.39) CYP3A4ALDH1A1SMN1; SMN2ALOX15TDP1
SCHEMBL8610624 0.74 ALDH1A1 (0.59) CYP3A4ALDH1A1SMN1; SMN2TDP1MAPT
SCHEMBL8611589 0.72 CYP3A4 (0.42) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL20659812 0.71 EPHX1 (0.40) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL9683129 0.70 MAPT (0.47) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL419643 0.70 PRSS1 (0.46) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL1980735 0.70 ALDH1A1 (0.53) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL29703904 0.70 ALDH1A1 (0.53) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5852017-A 2,3(1H,4H)-quinoxalinediones BASF AKTIENGESELLSCHAFT (DE) 1998-12-22 US disclosed
EP-0572852-B1 Quinoxalin-2,3(1H,4H)-diones used as medicine BASF AG (DE) 1998-10-21 EP disclosed
US-5714489-A 2,3(1H,4H)quinoxalinedione BASF AKTIENGESELLSCHAFT (DE) 1998-02-03 US disclosed
EP-0572852-A1 Quinoxalin-2,3(1H,4H)-diones used as medicine BASF Aktiengesellschaft (DE) 1993-12-08 EP disclosed