Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682901 | 0.90 | MAPT (0.43) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL11569274 | 0.90 | ALDH1A1 (0.49) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL11274390 | 0.89 | PKM (0.52) | MAPTALDH1A1SMN1; SMN2APPKDM4E | |
| SCHEMBL9681992 | 0.86 | HDAC8 (0.42) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL9683512 | 0.86 | TP53 (0.46) | ALDH1A1TSHRTP53 | |
| SCHEMBL9681343 | 0.86 | HDAC3 (0.44) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL9683167 | 0.86 | HTT (0.51) | MAPTL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9683493 | 0.86 | MEN1 (0.59) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL7171578 | 0.82 | CNR1 (0.47) | MAPTL3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL9682485 | 0.82 | GAA (0.51) | MAPTMEN1KMT2ASMN1; SMN2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |