Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8610763 | 1.00 | TSHR (0.32) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL25543 | 0.84 | TSHR (0.34) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL8444186 | 0.80 | TSHR (0.37) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL8611814 | 0.77 | PRSS1 (0.31) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL23725 | 0.73 | TSHR (0.31) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL7225298 | 0.72 | PRSS1 (0.33) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL11566611 | 0.71 | PRSS1 (0.31) | PRSS1CTSGCTRB1CMA1KDM4E | |
| SCHEMBL7225302 | 0.70 | PRSS1 (0.32) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL14582347 | 0.70 | ALDH1A1 (0.31) | KDM4EALDH1A1TDP1 | |
| SCHEMBL7231832 | 0.69 | PRSS1 (0.34) | TSHRPRSS1CTSGCTRB1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783602-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |
| EP-0741686-B1 | NEW LEUKOTRIENE B4 DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AG (DE) | 1998-04-22 | — | — | EP | disclosed |