Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27700737 | 0.86 | LMNA (0.40) | LMNAPDE4BPDE4DHSD17B10GAA | |
| SCHEMBL28416472 | 0.86 | LMNA (0.45) | LMNAPDE4BPDE4DHSD17B10GAA | |
| SCHEMBL2364931 | 0.84 | LMNA (0.41) | LMNAPDE4BPDE4DHSD17B10GAA | |
| SCHEMBL25601807 | 0.82 | LMNA (0.42) | LMNAPDE4BPDE4DHSD17B10GAA | |
| SCHEMBL28411151 | 0.78 | LMNA (0.38) | LMNAPDE4BPDE4DHSD17B10GAA | |
| SCHEMBL30554006 | 0.77 | ALDH1A1 (0.43) | LMNAGAAALDH1A1NPC1HPGD | |
| SCHEMBL30554033 | 0.73 | ALDH1A1 (0.40) | LMNAHSD17B10GAAALDH1A1NPC1 | |
| SCHEMBL9442396 | 0.72 | PI4KA (0.37) | LMNAHSD17B10GAAALDH1A1NPC1 | |
| SCHEMBL3237878 | 0.72 | PI4KA (0.37) | LMNAHSD17B10GAATP53THRB | |
| SCHEMBL4964108 | 0.72 | KDM4E (0.40) | LMNAGAATHRBHCAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770701-A | Process for preparing targeted forms of methyltrithio antitumor agents | AMERICAN CYANAMID COMPANY (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0313873-B1 | Targeted forms of methyltrithio antitumor agents | AMERICAN CYANAMID CO (US) | 1994-09-28 | — | — | EP | disclosed |
| EP-0313874-B1 | Disulfur analogs of LL-E33288 antitumor agents | AMERICAN CYANAMID CO (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5053394-A | Protein-drug reaction product | AMERICAN CYANAMID COMPANY (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0392384-A2 | Targeted forms of methyltrithio antitumor agents | AMERICAN CYANAMID COMPANY (US) | 1990-10-17 | — | — | EP | disclosed |
| EP-0313873-A1 | Targeted forms of methyltrithio antitumor agents | AMERICAN CYANAMID COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| EP-0313874-A2 | Disulfur analogs of LL-E33288 antitumor agents | AMERICAN CYANAMID COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |