Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 10/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 8/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852305 | 0.89 | NPC1 (0.48) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL860100 | 0.86 | ST14 (0.43) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL861820 | 0.86 | ST14 (0.56) | ST14PRSS1PRSS2PRSS3F2 | |
| SCHEMBL861872 | 0.84 | ST14 (0.42) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851954 | 0.81 | ST14 (0.48) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL862070 | 0.80 | ST14 (0.46) | ST14PRSS1PRSS2PRSS3F2 | |
| SCHEMBL851530 | 0.79 | ST14 (0.52) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851900 | 0.79 | ST14 (0.51) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851301 | 0.76 | ST14 (0.62) | NPC1ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851665 | 0.76 | ST14 (0.50) | NPC1ST14PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |