Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | IAPP | P10997 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8610924 | 0.87 | CYSLTR2 (0.43) | CYSLTR2CYSLTR1IMPDH1LTB4RLTB4R2 | |
| SCHEMBL8613208 | 0.85 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1IMPDH1LTB4RLTB4R2 | |
| SCHEMBL8610989 | 0.84 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1IMPDH1LTB4RLTB4R2 | |
| SCHEMBL8612091 | 0.81 | CYSLTR2 (0.40) | CYSLTR2CYSLTR1IMPDH1LTB4RLTB4R2 | |
| SCHEMBL8611172 | 0.73 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1IMPDH1LTB4RLTB4R2 | |
| SCHEMBL8611130 | 0.70 | PPARA (0.41) | CYSLTR2CYSLTR1LTB4RTSHR | |
| SCHEMBL8611371 | 0.69 | PPARA (0.39) | LTB4RTSHR | |
| SCHEMBL7328569 | 0.69 | TSHR (0.46) | IMPDH1TBXA2RALDH1A1TSHR | |
| SCHEMBL9848754 | 0.69 | HDAC11 (0.41) | IMPDH1IMPDH2TBXA2RALDH1A1TSHR | |
| SCHEMBL8611361 | 0.66 | PPARA (0.40) | LTB4RTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718295-B1 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis | ALFA WASSERMANN SPA (IT) | 1998-04-22 | — | — | EP | claimed |
| US-5608084-A | AND VASCULAR PATHOLOGIES; MULTISTEP PREPARATION BY REACTING A HYDROQUINONE WITH ALKYL VINYL KETONE, ESTERIFYING HYDROXY 3,4-DIHYDRO-2H-1-BENZOPYRAN, DEMETHYLATING ETHER, REACTING WITH ALKYL 5-BROMOPENTANOATE, HYDROLYZING, TWO MORE STEPS | ALFA WASSERMANN S.P.A. (IT) | 1997-03-04 | — | — | US | claimed |
| EP-0718295-A1 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis | ALFA WASSERMANN S.p.A. (IT) | 1996-06-26 | — | — | EP | claimed |
| EP-0718295-B1 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis | ALFA WASSERMANN SPA (IT) | 1998-04-22 | — | — | EP | disclosed |
| US-5608084-A | AND VASCULAR PATHOLOGIES; MULTISTEP PREPARATION BY REACTING A HYDROQUINONE WITH ALKYL VINYL KETONE, ESTERIFYING HYDROXY 3,4-DIHYDRO-2H-1-BENZOPYRAN, DEMETHYLATING ETHER, REACTING WITH ALKYL 5-BROMOPENTANOATE, HYDROLYZING, TWO MORE STEPS | ALFA WASSERMANN S.P.A. (IT) | 1997-03-04 | — | — | US | disclosed |
| EP-0718295-A1 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis | ALFA WASSERMANN S.p.A. (IT) | 1996-06-26 | — | — | EP | disclosed |