Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | DRD3 | P35462 | 5/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.58 |
| ▸ | DRD5 | P21918 | 4/20 | 0.58 |
| ▸ | HRH2 | P25021 | 4/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.58 |
| ▸ | HRH1 | P35367 | 4/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.58 |
| ▸ | HTR6 | P50406 | 4/20 | 0.58 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.58 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.58 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.58 |
| ▸ | DRD4 | P21917 | 4/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612001 | 0.95 | SLC6A3 (0.59) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| SCHEMBL7751327 | 0.89 | SLC6A3 (0.54) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| Hydrochloric Acid SCHEMBL7544797 | 0.88 | SLC6A3 (0.53) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| SCHEMBL4760958 | 0.83 | CYP3A4 (0.51) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| SCHEMBL8616378 | 0.83 | CYP3A4 (0.51) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| SCHEMBL8615736 | 0.83 | CYP3A4 (0.51) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| SCHEMBL9141600 | 0.82 | SLC6A3 (0.59) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| Hydrochloric Acid SCHEMBL8867248 | 0.82 | MEN1 (0.52) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| Hydrochloric Acid SCHEMBL7543578 | 0.82 | MEN1 (0.52) | SLC6A3HTR2ADRD3CACNA1FDRD5 | |
| SCHEMBL8611835 | 0.80 | DRD3 (0.49) | SLC6A3HTR2ADRD3CACNA1FDRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549796-B1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEM IND INC (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5391552-A | Has strong antagonism against calcium with less side effects | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0612738-A1 | Diphenylpiperazine derivative and drug for circulatory organ containing the same | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1994-08-31 | — | — | EP | disclosed |
| EP-0549796-A1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEMICAL INDUSTRIES INC (JP) | 1993-07-07 | — | — | EP | disclosed |