Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | F12 | P00748 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | GBA1 | P04062 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | F11 | P03951 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10442289 | 0.84 | KMT2A (0.65) | ALDH1A1HPGDHSD17B10CYP1A2ALOX15 | |
| Hydrochloric Acid SCHEMBL31460267 | 0.84 | KMT2A (0.63) | ALDH1A1HPGDHSD17B10CYP1A2ALOX15 | |
| SCHEMBL289400 | 0.81 | KDM4E (0.67) | ALDH1A1HPGDHSD17B10KMT2AF2 | |
| Hydrochloric Acid SCHEMBL31460331 | 0.81 | CA9 (0.63) | F12KMT2AGBA1MEN1POLB | |
| Hydrochloric Acid SCHEMBL7641797 | 0.80 | KDM4E (0.65) | ALDH1A1HPGDHSD17B10KMT2AF2 | |
| Hydrochloric Acid SCHEMBL381749 | 0.79 | KDM4E (0.64) | ALDH1A1HPGDHSD17B10KMT2AF2 | |
| Nafamostat SCHEMBL135503 | 0.77 | PRSS1 (0.64) | ALDH1A1F12F2F10PLG | |
| Nafamostat SCHEMBL29429445 | 0.77 | PRSS1 (0.64) | ALDH1A1F12F2F10PLG | |
| Nafamostat SCHEMBL29429443 | 0.77 | PRSS1 (0.64) | ALDH1A1F12F2F10PLG | |
| Nafamostat SCHEMBL16069975 | 0.77 | PRSS1 (0.64) | ALDH1A1F12F2F10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433642-A2 | Modified proteases that inhibit complement activation | Catalyst Biosciences, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |