Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | CLK1 | P49759 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | SLC27A1 | Q6PCB7 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | HBB | P68871 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357081 | 0.89 | SMN1; SMN2 (0.75) | LMNASMN1; SMN2TSHRUSP2MEN1 | |
| SCHEMBL8354632 | 0.86 | SMN1; SMN2 (0.85) | LMNASMN1; SMN2TSHRUSP2MEN1 | |
| Hydrochloric Acid SCHEMBL8358101 | 0.85 | SMN1; SMN2 (0.84) | LMNASMN1; SMN2TSHRUSP2MEN1 | |
| SCHEMBL3394423 | 0.80 | CLK1 (0.67) | SMN1; SMN2MEN1KMT2ACLK1POLB | |
| SCHEMBL28643433 | 0.80 | CLK1 (1.00) | SMN1; SMN2MEN1KMT2ACLK1POLB | |
| SCHEMBL4006366 | 0.78 | THRB (0.82) | LMNATSHRMEN1KMT2APOLB | |
| SCHEMBL4006313 | 0.78 | THRB (0.77) | LMNASMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL8353613 | 0.76 | ALDH1A1 (0.74) | LMNASMN1; SMN2TSHRUSP2KMT2A | |
| SCHEMBL8353601 | 0.75 | ALDH1A1 (0.70) | LMNASMN1; SMN2TSHRUSP2KMT2A | |
| SCHEMBL3392183 | 0.75 | CLK1 (0.65) | SMN1; SMN2MEN1KMT2ACLK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |