Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TYR | P14679 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612465 | 0.90 | ALDH1A1 (0.52) | POLBSMN1; SMN2HTTTYRALDH1A1 | |
| SCHEMBL8590962 | 0.88 | TYR (0.56) | POLBSMN1; SMN2HTTTYRALDH1A1 | |
| SCHEMBL8591572 | 0.88 | POLB (0.77) | POLBSMN1; SMN2HTTALDH1A1CYP1A2 | |
| SCHEMBL10888526 | 0.86 | POLB (0.73) | POLBSMN1; SMN2HTTALDH1A1CYP1A2 | |
| SCHEMBL10888531 | 0.84 | TYR (0.55) | POLBSMN1; SMN2HTTTYRALDH1A1 | |
| SCHEMBL6402141 | 0.80 | POLB (0.58) | POLBSMN1; SMN2HTTALDH1A1CYP1A2 | |
| SCHEMBL28026046 | 0.77 | POLB (0.51) | POLBSMN1; SMN2TYRALDH1A1CYP1A2 | |
| SCHEMBL27619507 | 0.77 | ALDH1A1 (0.68) | POLBSMN1; SMN2HTTALDH1A1CYP1A2 | |
| SCHEMBL27744035 | 0.77 | POLB (0.59) | POLBSMN1; SMN2ALDH1A1CYP1A2TDP1 | |
| SCHEMBL11235452 | 0.77 | POLB (1.00) | POLBSMN1; SMN2HTTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |